The RMG plays a crucial role in mixing and granulating powder ingredients to form granules, which are then used in the manufacturing of pharmaceutical tablets or capsules.

The High Shear Mixer Granulatorused forprocess offastdry & wet mixing,homogenizing,humidifying and granulating of the powder in Pharmaceutical.

overview of the Rapid Mixer Granulator:

1.Principle of Operation:

  • The Rapid Mixer Granulator operates based on the principle of mechanical agitation combined with a chopper. It combines dry powder ingredients with a binder solution to form wet granules.

2. Mixing and Wet Granulation:

  • Dry powders are loaded into the mixing bowl of the RMG. The impeller within the bowl rotates at a high speed to create a fluidized bed. Simultaneously, the binder solution is sprayed onto the powders. This results in the formation of wet granules through a process known as wet granulation.

3. Impeller and Chopper Mechanism:

  • The impeller provides the main mixing action by creating a vortex in the powder bed, ensuring even distribution of the binder. The chopper, equipped with blades, breaks down any oversized granules to achieve uniform granule size.

4. Temperature Control:

  • Temperature control is crucial during the granulation process. Some RMGs are equipped with a jacketed bowl to allow for temperature regulation, preventing excessive heat buildup.

5. Inlet for Powders and Binder:

  • The RMG typically has separate inlets for adding dry powders and the liquid binder. This allows for precise control over the addition rates.

6. Process Automation:

  • Many RMGs are designed with advanced control systems for automation. This includes control over mixing speed, binder addition rate, and chopper speed. Automation ensures reproducibility and consistency in the granulation process.

7. Cleaning and Validation:

  • The RMG is designed for easy cleaning between batches, an essential feature in pharmaceutical manufacturing to prevent cross-contamination. Validation procedures are often in place to ensure the equipment meets regulatory standards.

8. Safety Features:

  • RMGs are equipped with safety features, including interlocks and alarms, to ensure safe operation and protect the operators.

9. Scale-Up Capability:

  • RMGs are available in different sizes to accommodate various batch sizes. This scalability is crucial for pharmaceutical manufacturers who may need to produce different quantities of granules.

10. Integration with Downstream Equipment: – The granules produced by the RMG are often transferred to downstream equipment, such as a tablet press or capsule filling machine, for the final dosage form manufacturing.

The Rapid Mixer Granulator is an integral part of pharmaceutical solid dosage form manufacturing, contributing to the production of uniform and high-quality granules used in the creation of tablets and capsules.